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Prostacyclin receptor
・ Prostacyclin synthase
・ Prostaglandin
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・ Prostaglandin E2 receptor


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Prostacyclin receptor : ウィキペディア英語版
Prostacyclin receptor

Prostacyclin receptor ( or prostaglandin I2 receptor, IP1) is a receptor for prostacyclin, encoded by the PTGIR gene.

There are actually two receptors for prostacyclin, the other being IP2.
==Transduction==
When binding a prostacyclin-molecule, the receptor changes conformation and activates Gs, with its activation of cAMP and increase in protein kinase A (PKA) activity.
===In vasodilation===
In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. The smooth muscle relaxation leads to vasodilation.〔 Page 479 〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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